Then i compare to 2 other web based speed tests and they run very close to each other. When I use laptop it will show my almost 150 mbps out of possible 200. This app will tell me I only have 14 mbps while I actually pay for 200. When it searches for nearby signals, it shows that it reads from areas near 100 miles away from my home while the web based finds signals only 5 miles from home. I go on laptop and use another speed test that is much closer to reality. I have tried using this app many times and never get an accurate reading. Please update and let us know how it goes. We just updated the app to version 4.0.7, which should fix this problem. If/when that happens, I’ll gladly bump my rating up to five stars and send due praise in an updated review. With a simple filter option, though, that issue vanishes. Call it nitpicking, but it voids the usefulness of the “Notes” feature as an analytical tool. Scrolling through dozens and dozens of test results to find those with tagged with note icons so that they can be analyzed and cross-referenced while tracking long term connectivity performance is far too cumbersome and time-consuming. On top of that, the app continues to run as reliably and smoothly as ever.Īll that being said, however, I’ve found the “Notes” option for results less and less useful because of the inability to filter test results so that those with notes can be viewed separately. Just a great idea that provides very, very useful information in terms of gauging in-the-moment download/upload bandwidth capacity. The latest update introducing separate “multi” and “single” connections testing was a dandy. Sorry again, and thanks for using Speedtest! Sorry for the trouble! This issue should now be fixed in the most recent update, 5.0.2. Maybe I should’ve created a new account? Your account creation process has been confusing and buggy so maybe it’s just a glitch? Hopefully the next app update might fix this issue, I can’t be the only one having this issue, there should also be an option to sync your speed tests with iCloud like Shazam and allow us to import our CSV files that we exported prior to our tests disappearing. I really need your help to re-add all my speed tests back to the app, it would mean a lot if you could reply to this, I loved Speedtest so much but now I feel like it’s a little pointless if all of my speed tests are now gone. Once updating the app, and signing in, all of my Speedtest were gone, over two years worth of speedtests taken on Verizon, T-Mobile, and AT&T and Wi-Fi, but for some reason all my video tests are still there. I’ve loved this app over the past few years and I saw the latest Speedtest app update and I thought that it would be a great idea to update and sign in to my account to sync all of my speedtests but nooo that was a horrible idea. Loved this app but latest Speedtest update when signing into my account I removed all my Speedtests Go ad free! If you’d like to enjoy Speedtest without ads, we provide the option of removing ads from Speedtest for $0.99. Track past tests with detailed reporting Troubleshoot or verify the speed you were promised Test with a single connection to simulate downloading a file or multiple connections to understand max speed Real-time graphs show connection consistency Stay private and secure with our free Speedtest VPN Take a video test to measure your max resolution, load time, and buffering View mobile carrier coverage with Speedtest Maps Measure ping at 3 stages: idle, download, and upload Discover your download, upload, and jitter Millions of users have made Speedtest the #1 app for testing internet speed, and it’s trusted daily by professionals throughout the industry: Speedtest VPN Premium users will also receive no advertisements while their subscription is active. Use up to 2GB of data over VPN per month for free, or go Premium with unlimited usage for just $4.99 monthly. Keep your online connection private and secure with Speedtest VPN™. Take a video test to get actionable insights that help you optimize your online video experience. Video testing empowers you with a real-time assessment of your network’s current streaming quality. Easily switch between providers and regions to compare coverage in the locations you frequent. See performance by provider to find out where you’re likely to experience strong connectivity. Use Speedtest® for a quick, easy, one-tap connection internet speed test-accurate anywhere thanks to our global server network.Įxplore mobile network coverage with Speedtest Maps based on real-world data gathered by the Speedtest app.
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Whether or not Colossal and its team of scientists are ultimately successful in their quest to bring back the dodo and other extinct creatures, de-extinction projects, and the technological breakthroughs they may generate, have investors excited. It’s hard,” he said.īeth Shapiro, left, will lead the scientific efforts to resurrect the dodo at Colossal Biosciences, founded by tech entrepreneur Ben Lamm, right. “I’ve been trying for about 10 years to culture germ cells from other bird species. And that’s the big, hard part jumping from chicken species, which many labs in the world do, to other bird species,” said McGrew, who is not directly involved in the dodo project but is part of Colossal’s scientific advisory board. “The idea is you have to now be able to do this with pigeon species. Mike McGrew, a senior lecturer and personal chair in avian reproductive technologies at the Roslin Institute at the University of Edinburgh, described the project as a “moon launch for synthetic biology.” His work involves turning commercial egg-laying hens into surrogates for rare chicken breeds revived from frozen primordial germ cells. “If we find that there’s something that provides immunity against a disease that’s hurting a population, and you know what the genetic changes underlying that immunity or that ability to fight off that disease is - maybe we can use these tools to transfer that even between closely related species,” she added. it would be amazing to get this to work in lots of different birds across the bird tree of life because that will be hugely impactful for avian conservation,” Shapiro said. “This technology, which works in chickens…. The techniques could allow scientists to move specific genetic traits between bird species to help protect them as habitats shrink and the climate warms. However, Shapiro said that perfecting these synthetic biology tools will have wider implications for bird conservation. The approach involves removing primordial gems cells from an egg, cultivating them in the lab and editing the cells with the desired genetic traits before injecting them back to an egg at the same developmental stage, she explained.Įven if the team is successful in this high-stakes endeavor, they won’t be making a carbon copy of the dodo that lived four centuries ago, but an altered, hybrid form. Shapiro said she hopes to adapt an existing technique used involving primordial germ cells, the embryonic precursors of sperm and eggs, that has already been used to create a chicken fathered by a duck. However, the subsequent work that’s needed to resurrect the animal - programming cells from a living relative of the dodo with the lost bird’s DNA - will be significantly more challenging. It’s a process which would allow them to narrow down which mutations in the genome “make a dodo a dodo,” Shapiro said.Ī dodo skeleton on display at a museum in Mauritius. The next step was to compare the genetic information with the dodo’s closest bird relatives in the pigeon family - the living Nicobar pigeon, and the extinct Rodrigues solitaire, a giant flightless pigeon that once lived on an island close to Mauritius. Shapiro said that she had already completed a key first step in the project - fully sequencing the dodo’s genome from ancient DNA - based on genetic material extracted from dodo remains in Denmark. Shapiro is the lead paleogeneticist at Colossal Biosciences, a biotechnology and genetic engineering start-up founded by tech entrepreneur Ben Lamm and Harvard Medical School geneticist George Church, which is working on equally ambitious projects to bring back the woolly mammoth and the thylacine, or Tasmanian tiger. And it’s our responsibility to bring stories and to bring excitement to people in way that motivates them to think about the extinction crisis that’s going on right now,” said Beth Shapiro, a professor of ecology and evolutionary biology at the University of California, Santa Cruz. “We’re clearly in the middle of an extinction crisis. They hope the project will open up new techniques for bird conservation. Now, a team of scientists wants to bring back the dodo in a bold initiative that will incorporate advances in ancient DNA sequencing, gene editing technology and synthetic biology. They doomed the dodo, which showed no fear of humans, to extinction in the space of just a few decades. The arrival of sailors brought with them invasive species like rats and practices like hunting. No other animal is as inexorably linked with extinction as the dodo, an odd-looking flightless bird that lived on the island of Mauritius in the Indian Ocean until the late 17th century. It’s also making recommendations to the Small Business Administration on how to improve emergency lending to prevent future fraud. The committee forwarded the findings from the 129-page report to the Department of Justice for a possible criminal investigation. The owners of Elev8 Advisors-Blueacorn’s primary eligibility verification and compliance consultants-received PPP loans for themselves, their businesses, and their family members through Blueacorn’s lending partners.Reis claimed to be an African American and a veteran-both of which appear to be false. Hockridge received nearly $300,000 in PPP loans, some of which were facilitated by their own company. In addition to likely taking over $120 million in taxpayer-funded PPP processing fees as personal profit, Mr. Blueacorn’s founders arranged PPP loans for themselves through Blueacorn, some of which have signs of potential fraud.According to their former business partners, Blueacorn founders Reis and Hockridge attempted to directly charge some applicants a 10% fee for successfully procuring PPP loans-in violation of SBA rules.Blueacorn’s owners directed reviewers to prioritize “monster loans will get everyone paid” and created an exclusive category of PPP loans, called “VIPPP” loans. Blueacorn’s owners were dismissive of other loans, writing “delete them,” “who f***ing cares,” and “e’re not the first bank to decline borrowers who deserve to be funded… they go elsewhere.”.Blueacorn loan reviewers reported receiving poor training and being pressured to “push through” PPP loans, even if the reviewers doubted the authenticity of the loan’s supporting documents.It transferred nearly $300 million in profits to its owners while only spending $8.6 million-less than one percent of the fees it received for its PPP work on fraud prevention.
As an actress, she’s known for the films License to Kill (1989), Hollywood Homicide (2003) and Lee Daniels’ The Butler (2013). No stranger to performing, Knight put on her dancing shoes in 2012 when she joined the cast of ABC’s hit reality competition “Dancing with the Stars” for season 14, partnering with Tristan MacManus. Knight, a longtime Las Vegas resident, returned to the Strip in the late-2000s to the famed Tropicana Hotel for a special engagement that ran in the newly named Gladys Knight Theater, making her the first African-American performer to have a venue named after her in Las Vegas. In 2011, Knight was honored with a Legend Award alongside fellow recipients Earth, Wind & Fire on the BET broadcast of the 3rd annual Soul Train Awards, hosted by Cedric the Entertainer. A perfect blend of grace and grit has allowed her to record such masterpieces of balladry as “Neither One of Us (Wants to Be the First to Say Goodbye),” “If I Were Your Wom¬an,” “Midnight Train to Georgia” and “Every Beat of My Heart” while also making such funky dance numbers as the original “I Heard It Through the Grapevine,” “The Nitty Gritty,” “Friendship Train,” “I’ve Got to Use My Imagination” and “Love Overboard.” The key to this success is Knight’s voice, one of the more remarkable instruments of the rock, soul and R&B eras. Knight is one of the few Hall of Famers who have continued to make hits from the ‘60s until the present day. In 1996, Gladys Knight & The Pips were inducted into the Rock ‘N’ Roll Hall of Fame. All told, Knight has recorded more than 38 albums over the years. This seven-time Grammy winner has enjoyed #1 hits in Pop, Gospel, R&B and Adult Contemporary, and has triumphed in film, television and live performance. Once a part of the iconic Motown sound, The Empress of. Very few singers over the last fifty years have matched her unassailable artistry. on April 27, 2012, in the Mystic Showroom at Mystic Lake Casino. A double bill of classic 70s soul, featuring Gladys Knight (Midnight Train To Georgia, Best Thing That Ever Happened to Me) and The O’Jays (Love Train, Back Stabbers, I Love Music). No stranger to performing and light choreography over the course of her career, Knight raised the stakes when she put on her dancing shoes in the spring of 2012. The great ones endure, and Gladys Knight has long been one of the greatest. She has become a teacher, doctor, firefighter, astronaut and so much more.īarbie has also expanded past the range of just toy dolls. Since then Barbie has become so much more than just a fabulous fashion lover. The first Barbie fashion doll was originally launched over 60 years ago. On the coloring site, you can color drawings online using virtual tools, or you can download and print your favorite image on a printer for coloring with paints, pencils and felt-tip pens.It’s hard to think of a toy as popular or as iconic as Barbie. Created almost 60 years ago, the toy remains beloved and popular among girls all over the world to this day. Barbie prototypes in black and white are represented by a huge variety of images: a student, a skier, a surfer, a tennis player, a basketball player, a bride on a scooter or a motorcycle, and other models of the beloved American brand.Ī bright image, a fashionable wardrobe, a chic hairstyle, a flirtatious pretty face – for many, she is a real embodiment of femininity and beauty. The variety of images will allow you to captivate the child for a long time with a useful activity that develops thinking and trains the intellect. Any girl can create her own, cutest and most beautiful Barbie today – just go to the online coloring site, select the picture you like and decorate it with your favorite colors. Online coloring pages are a great option for expressing imagination and displaying creativity. And it is not always advisable to buy a daughter a lot of identical dolls, albeit in different images, because children do not always have a sense of the value of legendary toys. Fashionable Barbie dolls amaze with their variety of images, but few can afford to buy toys in various interpretations – the cost of the original Barbie and all kinds of accessories for her is not available to everyone. Barbie doll is to some extent a role model from completely different areas of our life, with her appearance she seeks to shed light on the infinity of the rights and opportunities of the fair sex of any social stratum of society. Over the years of its existence, it has become the personification of many professions and images – from a presidential candidate to an IT specialist with a simple haircut, in a simple T-shirt and jeans. The character of Barbie is multifaceted and does not fit into any framework of a certain image – the variety of all kinds of styles of appearance makes her a trendsetter in the fashion world, not only a toy, but also a real one. She is a reflection of different eras, the embodiment of female self-identity, individuality, uniqueness. What is the secret of her popularity and why did the doll-like blonde with blue eyes turn into a cult? Barbie is not just a pretty toy. Barbie Doll Student colouring page SEE ALL CATEGORIES OVER 1000 COLORING PAGES ON THE WEBSITE! Barbie Coloring Pages – Color and Explore Predictable expenses that aren’t paid as frequently (e.g., car maintenance)Įxamples of guilt-free spending as monthly expensesįinally, with the above essentials taken care of, you have your guilt-free spending left.Big-ticket purchases, like a down payment on a house or car.An emergency fund for unforeseen expenditures, from health care bills to computer repairs.Possible types of savings include extra money for: You can set up sub savings accounts to divert money for these distinct needs, making it easier to keep track. Savings can be used for various purposes. Retirement accounts like a 401(k) or Roth IRA.Investments could include monthly payments into the following: While some investments perform best long term, there are also short-term investment possibilities. Putting money into investments that grow can help your money keep up with inflation. Transportation costs like gas, car payments, or public transportation ticketsĮxamples of investments as monthly expenses.Food, including groceries, takeout, and restaurant dining.Utilities like electricity, gas, and water.Housing costs like rent, renters insurance, or mortgage payments.Although you can rarely cut fixed costs completely, reviewing them can help you find ways to reduce them. These are the things that you can’t eliminate because, let’s face it, you can’t really live without them. To make your conscious spending plan even clearer and easier to adhere to, it’s best to break it down into four distinct categories:įixed costs refer to expenses that you can’t forego. A monthly budget is also easier to manage than an annual budget since you have a smaller period to keep track of. This is also a manageable time frame to work with if you are employed and paid in a set period once or twice per month. Since many expenses (like rent) are inherently calculated on a monthly basis, most people make monthly budgets. This could include essentials like rent, utility bills, gas, food, child care, and health insurance, as well as nonessentials, like beauty treatments, entertainment (e.g., your Netflix subscription), and travel. So, just what qualifies as an expense? At its core, an expense is anything that you are spending money on - it’s the money that’s going out, not coming in. This guide explains how to calculate your expenses according to the conscious spending mindset. This makes for a sustainable approach to saving, investing, and general money management and can result in a more stable financial future. Instead of scrounging to save money, allow yourself those treats you truly enjoy while cutting costs on those things that don’t improve your happiness or quality of life. When setting up your 2023 budget, try a “conscious spending” approach. While the thought of examining the money you spend may be daunting at first, this is one of the first steps in setting a monthly budget that works for you (i.e., one that covers your basic needs and wants without leaving you feeling like you’re living a life of denial).
The same year, Ryan returned to type, starring alongside Tim Robbins in Fred Schepisi's romantic comedy I.Q. A critic for Variety called the film "a first-class production, accentuated by fine performances and an unflinching script," and another praised Ryan for her "roller-coaster role." The film was a notable success, grossing $50 million in the United States alone, and garnered Ryan her first Screen Actors Guild Award nomination. The film and her performance were both well-received by critics. In 1994, Ryan played an alcoholic high-school guidance counselor – far from the romantic-comedy ingenue roles for which she had become famous – in Luis Mandoki's romantic social drama When a Man Loves a Woman, also starring Andy Garcia. (Hanks and Ryan were once again paired in another box office success, You've Got Mail, in 1998.) She was offered the role of FBI agent Clarice Starling, the protagonist of The Silence of the Lambs (1991), but rejected it due to the film's gruesome and violent themes. They had previously been the romantic leads, with Ryan playing three different women, in John Patrick Shanley's Joe Versus the Volcano in 1990 - a commercial disappointment which later developed a cult following. In 1993, the hugely successful romantic comedy Sleepless in Seattle paired Ryan for a second time with Tom Hanks. Ryan next appeared in Oliver Stone's moderately successful film The Doors, and in Prelude to a Kiss, which flopped. Her portrayal of Sally Albright includes an oft-recounted scene in which her character, lunching with Crystal's character in Katz's Delicatessen in Manhattan, theatrically demonstrates for him how easy it is for a woman to fake an orgasm. (1989), which paired her with comic actor Billy Crystal and earned her a Golden Globe nomination. Ryan's first leading role was the romantic comedy film When Harry Met Sally. She also costarred in 1988 with Sean Connery and Mark Harmon in The Presidio. Ryan appeared in the film Innerspace in 1987 with her future husband Dennis Quaid, and they subsequently costarred in the remake of D.O.A. Scenes with them were reprised in the 2022 sequel Top Gun: Maverick as flashbacks, to illustrate the emotional conflicts between lead character Pete "Maverick" Mitchell ( Tom Cruise) and the Bradshaws' grown son, Bradley "Rooster" Bradshaw ( Miles Teller). In 1986, she played Carole Bradshaw, the wife of Anthony Edwards' character, naval flight officer Nick "Goose" Bradshaw, in Top Gun. Her role in Promised Land (1987) earned Ryan her first Independent Spirit Award nomination. Several television and smaller film roles followed, including appearances in Charles in Charge, Armed and Dangerous, Amityville 3-D. She also appeared in some television commercials during the early 1980s for Burger King and Aim toothpaste, among others. Career Early workĪfter her film debut in director George Cukor's final film, Rich and Famous in 1981, Ryan played Betsy Stewart in the daytime drama As the World Turns from 1982 to 1984 her character was featured in a popular romantic story arc. When she joined the Screen Actors Guild, she used the surname "Ryan", her grandmother's maiden name. Her success as an actress led her to leave college a semester before she planned to graduate. During college, she acted in television commercials and the soap opera As the World Turns to earn extra money. She studied journalism as an undergraduate, first at the University of Connecticut and then at New York University. Ryan graduated from Bethel High School in 1979. Her parents divorced in 1976 when she was 15. She has two sisters, Dana and Annie, and a brother, musician Andrew Hyra, a member of the band Billy Pilgrim. Ryan was born and raised in Fairfield, Connecticut, to Susan Jordan ( née Duggan), a former actress and English teacher, and Harry Hyra, a math teacher. In 2015, she made her directorial debut with Ithaca, in which she also starred. (1989), for which she earned a Golden Globe nomination.Ī prolific actress through the 1990s and 2000s, Ryan appeared in When Harry Met Sally (1989), Joe Versus the Volcano (1990), The Doors (1991), Sleepless in Seattle (1993), When a Man Loves a Woman (1994), French Kiss (1995), Courage Under Fire (1996), Anastasia (1997), Addicted to Love (1997), You've Got Mail (1998), City of Angels (1998), Proof of Life (2000), Kate & Leopold (2001), and The Women (2008). In the 1980s, Ryan appeared in Top Gun, Promised Land (1987) and the Rob Reiner-directed romantic comedy When Harry Met Sally. She joined the cast of the CBS soap opera As the World Turns in 1982. She made her acting debut in 1981 in the drama film Rich and Famous. Meg Ryan (born Margaret Mary Emily Anne Hyra November 19, 1961) is an American actress. While that's going down Luger and Levitt bring in one Alfred Royce, who is being arrested for armed robbery. He reveals that a group of operators were luring homeless people from shelters with the promise of free gin, sticking them into vans, and driving them to North Carolina, where they were pressed into service as agricultural laborers picking crops. Finally, Harris shows up at the 12th Precinct with a flock of a half-dozen hobos. Eventually they get a call from Harris in North Carolina. The 12th puts out an APB, using the only photo of Harris they have available, namely, his author's photo on the back cover of his book "Blood on the Badge". Harris, having gone undercover at a homeless shelter to investigate reports of disappearing vagrants, has himself disappeared. "Vanished: Part 2" is the 14th episode of the sixth season of Barney Miller.Įvents follow upon the previous week's episode, "Vanished: Part 1". Guest Starring: James Gregory, Elaine Giftos, John Dullaghan, Leonard Frey Written by: Frank Dungan, Jeff Stein, and Tony Sheehan I'm a man with a record Barney, you think they're going to force ME out? NOT ME! A man with my experiences? My accommodations? NOT ME!. This is not the last day of your life Fish. I'll talk to him and everything's gonna be alright. Rules are made by men and rules can be changed by men! I know the Commissioner, I've known him for 20 years and I'm going to have a talk with him. You know, the trouble this city is in and you know how hard it is to get good men Barney. I had a lot of time to think things over. Fish, you've earned the right to do something else, to do what you want to do, what you'd enjoy doing. but you've got to face the reality, that IS the reality and you gotta face it or you'll wind up like that 'twinkie' in the cage out there. you got it all wrong Barney, I'm not retiring so fast.įish, I know it's painful and it's even unfair. There is no more work! You are retiring today! Look, if I don't finish I'll have to work late on Monday. The kind of things friends who've worked together for 18 years talk about. Yes, Well, I better get in there & finish processing that felon.Ī lot. You've done a very good job, you've got a lot to be proud of. So it's a good thing they some of us around to keep a balance huh? Can you believe a punk like that, what's this world coming to? When I'm too old to take care of a guy like you. I'll give you old guy, SIT DOWN! As long as there's punks out there like you, I'll be here in this room and at that desk! So you watch yourself!. That old guy really 'loves' his work don't he? The guy came out just as we got there and 'ol Fish just chased him down the street, jumped on him a got his face down to the sidewalk. Harold Sanders, Barney, he robbed a liquor store on 14th street. It was going' good until these guys showed up. I'm not a wise guy, I guess I'm just scared. Who cares whose case it is? Just get the door open! Nobody's answering the phone! I've got to cover the rest of the building!Īren't those the keys on the desk? If you ever catch the lunatic who did this tell him to call me. Wilson, get out of here! There's a bomb in the building! _ programs and features are often integrated into video editing software. And it seamlessly integrates with Adobe apps like After Effects, when you subscribe to Creative. Adobe Premiere Pro is an industry-standard video editing program that's really easy to use. Programs and features are often integrated into video editing software package. But Adobe's program is the most well-rounded of all the video editing software we've tested. The game produces at least 1 billion bits of information at 60 frames per second for display. Check Current Price Searching for the right software can be confusing, so I’ve written this guide to help save you some time and money. Adobe Premiere Pro Familiar editing interface, powerful tools and seamless integration with Adobe apps caters perfectly to multimedia content creators. It's the video editing program used by professionals the world over, thanks to its user-friendly. Premiere Pro is our pick of the best video editing software overall. What We Don't Like Limited features available. Plenty of tools to improve video and audio quality. craiglist wichita falls 01 of 06 Best Video Editor For Mac: iMovie What We Like Easy-to-use interface. Adobe Premiere Pro: starting at $20.99/month Premiere Pro is the video editing program used by professionals the world over, but it's also a fine choice for everyone else, thanks to its. A) Virtual reality B) Computer-aided technology C) Audio-editing D) Simulation C:Audio-editing A bitmap image is provided in two different resolutions. Programs and features are often integrated into video editing software Whilemanysoftwareprogramsaregearedtowardconsumersprofessional quality from COSC 1301 at Austin Community College DistrictWhilemanysoftwareprogramsaregearedtowardconsumersprofessional quality from COSC 1301 at Austin Community College District_programs and features are often integrated into video editing software. USH1G patients are profoundly deaf and have no balance function at birth, and they subsequently suffer from prepubertal-onset sight loss leading to blindness. The various hereditary forms of hearing loss include Usher syndrome type 1 (USH1), a particularly severe clinical form of deaf-blindness, and specifically the USH1G genetic form. To date, mutations in more than 100 genes have been associated with inner ear defects, and it is estimated that mutations in more than 100 genes can cause genetic forms of deafness. The inner ear comprises the hearing organ or cochlea, together with the five balance organs (the saccule, utricle and three semicircular canals), which contain the sensory cells, or hair cells, that detect mechanical vibrations and convert them into electrical signals. Over the past 20 years, scientists have made remarkable progress in deciphering the genetic origins of congenital hereditary hearing loss, which is usually caused by inner ear dysfunction. In France, one child in 700 is born with severe or profound hearing loss, and one in every 1,000 will lose their sense of hearing before adulthood. Hearing loss, sometimes associated with other disorders such as balance defects, is the most common sensory deficit, affecting more than 280 million people worldwide, according to WHO. These findings, published in the journal PNAS, open up new possibilities for the development of gene therapy treatments for hereditary forms of deafness. By locally injecting the USH1G gene, critical for the formation and maintenance of the hair bundle, the mechanosensory antenna of these cells, the scientists successfully restored the function and the structure of this apparatus, resulting in the first recovery of hearing and balance by gene therapy for this mouse model. Scientists from the Institut Pasteur, Inserm, the CNRS, Collège de France, University Pierre et Marie Curie, and University Clermont Auvergne*, have recently restored hearing and balance in a mouse model of Usher syndrome type 1G (USH1G) characterized by profound congenital deafness and vestibular disorders caused by severe dysmorphogenesis of the mechanoelectrical transduction apparatus of the inner ear’s sensory cells. |
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